supervised the project, obtained funding, and co-wrote the manuscript. did the design of the experiments, patient recruitment and collection of data. conducted OC quantification assay and co-wrote the manuscript. T1 - Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis In postmenopausal women with osteoporotic fractures, supplementation with either 5 or 45 mg/day of MK-4 reduces ucOC to concentrations typical of healthy, pre-menopausal women.", There were no major side effects of MK-4 supplementation. MK-4 supplementation resulted in borderline increases in γ-carboxylated osteocalcin (glaOC p = 0.07). However, compared to 5 mg/day, there was no additional benefit of 45 mg/day (%ucOC 4.6 p = NS vs. As compared to baseline concentrations (geometric mean ± SD) of 16.8 ± 2.4, 0.5 mg supplementation halved %ucOC to 8.7 ± 2.2 (p < 0.0001) and the 5-mg dose halved %ucOC again (to 3.9 ± 2.2 p = 0.0002 compared to 0.5-mg dose). bisphosphonates) correlated with improvement in %ucOC. MK-4 dose (p < 0.0001), but neither age nor other relevant medications (e.g. The mean ± SD age of the participants was 69 ± 9 years. Participants took low-dose MK-4 (0.5 mg) for 3 weeks (until the second visit), then medium-dose MK-4 (5 mg) for 3 weeks (until the third visit), then high-dose MK-4 (45 mg) for 3 weeks. A nine-week, open-labeled, prospective cohort study was conducted in 29 postmenopausal women who suffered hip or vertebral compression fractures. The objective of this study was to assess the improvement in carboxylation of osteocalcin (OC) in response to escalating doses of MK-4 supplementation. Although vitamin K2 (MK-4) is approved as a therapeutic agent for the treatment of osteoporosis in some countries, the doseresponse is unknown.
![vitamin k2 mk4 vitamin k2 mk4](https://omegavia.com/wp-content/uploads/2015/04/Vitamin-K2-supplement-MK-4-MK-7-blogad576px.jpg)
In postmenopausal women with osteoporotic fractures, supplementation with either 5 or 45 mg/day of MK-4 reduces ucOC to concentrations typical of healthy, pre-menopausal women.Ībstract = "Low concentrations of serum vitamin K accompany high concentrations of undercarboxylated osteocalcin (ucOC) and osteoporotic fractures.
![vitamin k2 mk4 vitamin k2 mk4](https://images-na.ssl-images-amazon.com/images/I/61sqNaenGzL._AC_SL1000_.jpg)
![vitamin k2 mk4 vitamin k2 mk4](https://www.gnc.com/dw/image/v2/BBLB_PRD/on/demandware.static/-/Sites-master-catalog-gnc/default/dwa0925fd8/hi-res/686166_1.jpg)
Low concentrations of serum vitamin K accompany high concentrations of undercarboxylated osteocalcin (ucOC) and osteoporotic fractures.