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Your doctor may need to change the doses of your medications and will monitor you carefully. Tell your doctor if you are taking or plan to take any of the following medications: benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion) medications for mental illness or nausea muscle relaxants other narcotic pain medications sedatives sleeping pills or tranquilizers. Taking certain medications during your treatment with hydromorphone may increase the risk that you will develop serious or life-threatening breathing problems, sedation, or coma. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath. The risk that you will develop breathing problems may be higher if you are an older adult, or are weakened or malnourished due to disease. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (a group of diseases that affect the lungs and airways), a head injury, a brain tumor, or any condition that increases the pressure in your brain, or kyphoscoliosis (curving of the spine that may cause breathing problems). Your doctor will probably tell you not to take hydromorphone. Tell your doctor if you have slowed breathing or have or have ever had asthma. Your doctor will monitor you carefully during your treatment.
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Hydromorphone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP. Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. There is a greater risk that you will overuse hydromorphone if you have or have ever had any of these conditions.
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Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. While you are taking hydromorphone, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. Hydromorphone may be habit forming, especially with prolonged use.